Numerical comparison of iodine-based and indium-based antibody biodistributions.
Identifieur interne : 000101 ( Main/Exploration ); précédent : 000100; suivant : 000102Numerical comparison of iodine-based and indium-based antibody biodistributions.
Auteurs : RBID : pubmed:24443889Abstract
Single-step iodination is often performed in preference to use of a radiometal label for initial animal biodistributions. Yet loss of iodine occurs in vivo so that it is important to measure uptake (%ID/g) differences between radiolabels.
DOI: 10.1089/cbr.2013.1564
PubMed: 24443889
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Numerical comparison of iodine-based and indium-based antibody biodistributions.</title><author><name sortKey="Williams, Lawrence E" uniqKey="Williams L">Lawrence E Williams</name><affiliation wicri:level="2"><nlm:affiliation>1 Division of Diagnostic Radiology, City of Hope National Medical Center , Duarte, California.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>1 Division of Diagnostic Radiology, City of Hope National Medical Center , Duarte</wicri:cityArea></affiliation></author><author><name sortKey="Wu, Anna M" uniqKey="Wu A">Anna M Wu</name></author><author><name sortKey="Kenanova, Vania E" uniqKey="Kenanova V">Vania E Kenanova</name></author><author><name sortKey="Olafsen, Tove" uniqKey="Olafsen T">Tove Olafsen</name></author><author><name sortKey="Yazaki, Paul J" uniqKey="Yazaki P">Paul J Yazaki</name></author></titleStmt><publicationStmt><date when="2014">2014</date><idno type="doi">10.1089/cbr.2013.1564</idno><idno type="RBID">pubmed:24443889</idno><idno type="pmid">24443889</idno><idno type="wicri:Area/Main/Corpus">000206</idno><idno type="wicri:Area/Main/Curation">000206</idno><idno type="wicri:Area/Main/Exploration">000101</idno></publicationStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Single-step iodination is often performed in preference to use of a radiometal label for initial animal biodistributions. Yet loss of iodine occurs in vivo so that it is important to measure uptake (%ID/g) differences between radiolabels.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">24443889</PMID><DateCreated><Year>2014</Year><Month>03</Month><Day>21</Day></DateCreated><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1557-8852</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>3</Issue><PubDate><Year>2014</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Cancer biotherapy & radiopharmaceuticals</Title><ISOAbbreviation>Cancer Biother. Radiopharm.</ISOAbbreviation></Journal><ArticleTitle>Numerical comparison of iodine-based and indium-based antibody biodistributions.</ArticleTitle><Pagination><MedlinePgn>91-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1089/cbr.2013.1564</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">Single-step iodination is often performed in preference to use of a radiometal label for initial animal biodistributions. Yet loss of iodine occurs in vivo so that it is important to measure uptake (%ID/g) differences between radiolabels.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Murine biodistributions of four radioiodinated and (111)In-labeled cognate anti-carcinoembryonic antigen antibodies were compared. Uptakes were obtained in athymic mice out to 96 hours for diabody, minibody, scFv-Fc, and intact humanized (M5A) versions of the T84.66 antibody. Tissues included liver, spleen, kidneys, lungs, and human LS174T colorectal xenografts. Ratios (R) of iodine uptake to indium uptake were calculated.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">For all cognates, no significant differences were found in the blood uptakes between the two labels. In normal solid organs, iodine was generally cleared more rapidly with decreasing molecular weight (MW). In liver and spleen by 24 hours, the R value was 5% for diabody and minibody, whereas a value of 50% was seen for the intact mAb. Renal differences were even more marked for the two lower MW species. Tumor losses, however, were found to be essentially independent of MW and were modest; 50% by 48 hours. To test the generality of the results, comparisons were then made for normal organs and tumors of the R values found above for M5A and MN-14 intact antibody literature results. Good agreement, within estimated errors in R, was seen between these two cases, although (111)In and (88)Y were the respective radiometals.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Loss of iodine from labeled antibodies can be marked in normal organs and that correction (by 1/R) of the iodine biodistribution to estimate the associated radiometal result may be possible. Explicit differences between the two types of biodistribution also imply that separate uptake results need to be considered when evaluating the impact on imaging and therapy using various possible radiolabels.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Williams</LastName><ForeName>Lawrence E</ForeName><Initials>LE</Initials><Affiliation>1 Division of Diagnostic Radiology, City of Hope National Medical Center , Duarte, California.</Affiliation></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Anna M</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Kenanova</LastName><ForeName>Vania E</ForeName><Initials>VE</Initials></Author><Author ValidYN="Y"><LastName>Olafsen</LastName><ForeName>Tove</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Yazaki</LastName><ForeName>Paul J</ForeName><Initials>PJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>01</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cancer Biother Radiopharm</MedlineTA><NlmUniqueID>9605408</NlmUniqueID><ISSNLinking>1084-9785</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2014</Year><Month>1</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>1</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>1</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>1</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1089/cbr.2013.1564</ArticleId><ArticleId IdType="pubmed">24443889</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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